Organometallic Compounds
Medchemexpress LLC PEG3-C4-OBn | 2381196-79-6 | 99.3% | 50 MG
PEG3-C4-OBn is a polyethylene glycol (PEG)-based PROTAC linker. It can be used in the synthesis of the PROTAC SGK3 degrader-1, a potent SKG3 degrader based on PROTAC.
- Polyethylene glycol (PEG)-based PROTAC linker
- Used in synthesis of PROTAC SGK3 degrader-1
- Potent SKG3 degrader
- Related to cancer research
- Related to cancer targeted therapy
Medchemexpress LLC Ms-PEG5-t-butyl ester | 870487-48-2 | MFCD20926382 | 95.0% | C16H32O9S | 10MG
Ms-PEG5-t-butyl ester is a PEG-based linker featuring a t-butyl-protected carboxyl group, designed for use in the chemical synthesis of PROTAC molecules. It provides a hydrophilic spacer to connect ligands while masking the carboxylate during multi-step syntheses.
- Provides a hydrophilic polyethylene glycol spacer to improve solubility.
- Contains a t-butyl-protected carboxyl group for orthogonal protection during synthesis.
- Compatible with standard coupling and deprotection chemistries used in medicinal chemistry.
- Facilitates assembly of bifunctional degraders by spacing ligands and reducing steric hindrance.
- Available in small-scale quantities suitable for research and discovery workflows.
- Reported high purity suitable for synthetic applications; verify with certificate of analysis.
Medchemexpress LLC HO-PEG3-(CH2)6-Cl | 1355955-95-1 | MFCD32705069 | 98.0% | 268.78 g/mol | C12H25ClO4 | 25 MG
HO-PEG3-(CH2)6-Cl is a PEG3-based PROTAC linker containing a six-carbon chloroalkyl spacer and a terminal hydroxyl. It is supplied as a small-mass research chemical for use in chemical biology and targeted protein degradation research.
- PEG3 spacer with flexible ether linkages.
- Terminal hydroxyl and chloro groups for orthogonal conjugation.
- Molecular formula C12H25ClO4 and molecular weight 268.78 g/mol.
- Provided as a 25 mg research sample.
- Intended for research use; consult product documentation for storage and purity.
Medchemexpress LLC Nh2-peg5-c6-cl hydrochloride | 2241669-16-7 | 98.0% | 5 G
NH2-PEG5-C6-Cl hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Bromoacetamido-PEG3-C2-Boc | 1807537-33-2 | C15H28BrNO6 | 250 MG
Bromoacetamido-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs are composed of two different ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein. PROTACs work by utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Available in various quantities
- Appears as a colorless to light yellow liquid
Medchemexpress LLC m-PEG3-Aminooxy | 248275-10-7 | 98.0% | C7H17NO4 | 50 MG
m-PEG3-Aminooxy is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, where one binds to an E3 ubiquitin ligase and the other to the target protein. They function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Utilized in the synthesis of PROTACs.
- Acts as a PEG-based PROTAC linker.
- Leverages the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Intended for research use only.
Medchemexpress LLC N-(Amino-PEG5)-N-bis(PEG4-acid) | 2093152-86-2 | 99.5% | 50 MG
N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG derivative that contains an amino group and two terminal carboxylic acids. The amino group is reactive with carboxylic acids and activated NHS esters. The terminal carboxylic acids can react with primary amine groups in the presence of activators to form a stable amide bond. This compound is useful in the development of antibody drug conjugates (ADCs).
- Contains an amino group and two terminal carboxylic acids
- Amino group is reactive with carboxylic acids and activated NHS esters
- Terminal carboxylic acids can react with primary amine groups
- Forms a stable amide bond
- Useful in the development of antibody drug conjugates (ADCs)
- For research use only
Medchemexpress LLC Calcein (tetraethyl ester) | 1170856-93-5 | 99.5% | 100 MG
Calcein tetraethyl ester is a fluorescent dye used in biology for testing cell viability and short-term cell labeling. It can be transported through the cellular membrane into live cells.
- Molecular weight: 734.75
- Formula: C38H42N2O13
- Appearance: Solid
- Color: Light yellow to yellow
- Emission (Em): 515
- Excitation (Ex): 489
- Solubility in DMSO: 25 mg/mL
- Insolubility in H2O: < 0.1 mg/mL
Medchemexpress LLC THP-PEG3-OH | 60221-37-6 | 98.7% | 5 G
THP-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- Can be used in the synthesis of PROTACs
- Contains two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC THP-PEG3-OH | 60221-37-6 | 98.7% | 1 G
THP-PEG3-OH is a PEG-based PROTAC linker used in the synthesis of PROTACs. This compound is intended for research use only and is not sold to patients.
- Enables the synthesis of PROTACs
- Functions as a PROTAC linker
- Utilizes the PROTAC pathway
- Facilitates selective degradation of target proteins via the ubiquitin-proteasome system
Medchemexpress LLC Mal-PEG5-acid | 1286755-26-7 | ≥97.0% | 50 MG
Mal-PEG5-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. This product is for research use only.
- Molecular weight of 389.40
- Chemical formula C17H27NO9
- Appears as a liquid, light brown to yellow in color
- Functions as a PROTAC linker, connecting two ligands
- Enables targeted protein degradation via the ubiquitin-proteasome system
Medchemexpress LLC Pomalidomide-PEG3-C2-NH2 hydrochloride | 2446474-09-3 | 96.6% | 25 MG
Pomalidomide-PEG3-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates the Pomalidomide based cereblon ligand
- Utilizes a 3-unit PEG linker
- Used in PROTAC technology
- Targets E3 Ligase Ligand-Linker Conjugates
- Pathway is PROTAC
- IC50 & Target is Cereblon
Medchemexpress LLC Tos-PEG5-Boc | 581065-94-3 | ≥97.0% | 1 G
Tos-PEG5-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. These compounds consist of two distinct ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other targeting the protein intended for degradation. PROTACs leverage the intracellular ubiquitin-proteasome system for selective protein degradation.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Molecular weight: 476.58
- Chemical formula: C22H36O9S
- Appears as a viscous liquid
- Colorless to light yellow
Medchemexpress LLC Pomalidomide-PEG3-C2-NH2 hydrochloride | 2446474-09-3 | 96.6% | 100 MG
Pomalidomide-PEG3-C2-NH2 hydrochloride is an E3 ligase ligand and linker conjugate. It is utilized in PROTAC technology for designing and developing novel targeted inhibitors. The E3 ligase ligand component, such as Pomalidomide, binds to a specific E3 ligase, while a linker connects it to a ligand that recognizes a targeted protein, a mechanism crucial for PROTAC activity.
- Functions as an E3 ligase ligand for Cereblon.
- Used in PROTAC technology.
- Aids in designing and developing novel targeted inhibitors.
Medchemexpress LLC Bis-PEG3-acid | 96517-92-9 | 97.0% | 250 MG
Bis-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Intended for research use only
- Not sold to patients
- Viscous liquid appearance
- Colorless to light yellow color